Ask your doctor about your own risk. to treat osteoporosis in males* and in females* whove gone through, to treat osteoporosis caused by long-term use of, metabolic bone disease, such as Hajdu-Cheney syndrome and juvenile. Osteoporosis is a condition that weakens your bones, making them more susceptible to fractures. Prolia may cause several side effects. Any advice? You may need to have a negative pregnancy test before starting this treatment. The conditions and factors to consider include: Upcoming dental procedures. Please know that the sponsors of this site are not responsible for content on the site you are about to enter. If the side effects seem life threatening or you think youre having a medical emergency, immediately call 911 or your local emergency number. Its also recommended that you use birth control while taking Prolia and for 5 months or more after your last dose. Symptoms can be mild or serious and can include: For mild symptoms of an allergic reaction, call your doctor right away. Prolia can also increase this risk. Prolia is available as the biosimilar medication denosumab. For example, in the studies, people taking Prolia for up to 8 years didnt have significant side effects compared with people taking a placebo. Its a prescription drug thats used to treat osteoporosis and other forms of bone loss. Costs of prescription drugs can vary depending on many factors. They can give you more details about this possible side effect and suggest ways to manage it. Talk with your doctor about which medication is right for you. Prolia If youd like to learn more about Prolia, talk with your doctor or pharmacist. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. Prolia may lower the level of calcium in your blood. Here are a few questions to consider asking your doctor: You can also learn more about osteoporosis treatment options here. These factors include what your insurance plan covers. They can treat the infection as needed. To help prevent low calcium, your healthcare provider may also After your treatment with Prolia is stopped, or if you skip or delay taking a dose, your risk for breaking bones, including bones in your spine, is increased. Research has shown people who take Prolia are at an increased risk of serious infections leading to hospitalizations, including endocarditis and serious infections of the skin, abdominal, urinary tract, and ear. Your doctor will recommend the dosage of Prolia thats right for you. So be sure to tell your doctor about all your health conditions before taking Prolia. kidney disease (or if you are on dialysis); a weak immune system (caused by disease or by using certain medicines); hypoparathyroidism (decreased functioning of the parathyroid glands); any condition that makes it hard for your body to absorb nutrients from food (malabsorption); if you are scheduled for a dental procedure; if you cannot take daily calcium and vitamin D; or. Get the treatment that fits your lifestyle, Stay informed with courtesy reminders, recipes and so much more. What do I need to be aware of if I need a tooth extraction while Im using Prolia? Theyll likely suggest other treatment options for your condition. Here are a few tips that might help guide your discussion: Remember, your doctor and other healthcare professionals are available to help you. Your doctor or pharmacist can tell you about any interactions these may cause with Prolia. Youll receive 60 mg/mL of Prolia once every 6 months. Advertising on our site helps support our mission. (Hint: it's not just. Although both drugs are approved to treat similar conditions, they work in different ways. Your doctor will explain how Prolia will be given to you. But some females* who received Prolia for osteoporosis after menopause had to stop Prolia treatment due to back pain. RA is an autoimmune condition in which your immune system attacks your joints. 2,4. You should also talk with them if you have any serious side effects during Prolia treatment. Osteoporosis Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. You may want to know how Prolia compares to the medication Tymlos. Prolia contains the active drug denosumab, while Tymlos contains the active drug abaloparatide. Fracture in the spine after stopping Prolia treatment. Try to avoid being around people who are sick. Heres a short list of some of the mild side effects that Prolia can cause. They can tell you more about benefits and risks of Prolia and Forteo. Mild side effects of Prolia that have been reported include: Mild side effects of many drugs may go away within a few days or a few weeks. Terms of Use. For example, if you have a serious UTI or other infection, call your doctor right away. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. But nausea may be a symptom of side effects such as vertigo or constipation. But if the side effects last longer than that, bother you, or become severe, be sure to talk with your doctor or pharmacist. In fact, bone breakdown is higher in the first several months after you stop Prolia. Our phase IV clinical studies alone cannot establish cause-effect relationship. for breast cancer that has not spread to other parts of the body. Some research has shown that alcohol consumption may increase your risk of osteoporosis, a bone fracture or impaired healing after a fracture. Calcium and Vitamin D: A major role of vitamin D is to help the body absorb calcium and maintain bone density. Examples of conditions Prolia is used off-label to treat include: Prolia is one option available to treat osteoporosis and reduce bone loss in people with a high risk for bone fracture. Studies of Prolia didnt report weight gain as a side effect of the drug. A healthcare provider will give you this injection. If youd like more information about Prolia use during pregnancy or while breastfeeding, talk with your doctor. you can take. I am taking Prolia and just saw that it's important to take Calcium because Prolia takes the calcium out of the blood and that can cause problems. Call your doctor or health care professional for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. Xgeva is another brand of denosumab that treats high calcium levels caused by cancer and prevents bone breaks. It can have some side effects, but these may depend on who uses it. We do not endorse non-Cleveland Clinic products or services. Theyll discuss with you other treatments to help prevent bone loss. Your dentist may have you use a chlorhexidine mouth rinse before and after surgery to reduce your risk for jaw-related side effects. Protect from light and do not freeze. For more information on this side effect, see Side effect specifics below. Biosimilars usually cost less than brand-name drugs. 1 shot every 6 months could mean fewer doses. Will my fracture risk come back if I stop Prolia treatment? Talk with your doctor if youd like to know about taking generic denosumab. These side effects may include: Its not known what percentage of people in clinical trials developed dental or jaw-related side effects. If you have osteoporosis or bone loss, your doctor may discuss Prolia as a treatment option. What should I know about Prolia vs. Xgeva? Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Over time, Prolia helps to improve the density and strength of your bones by slowing bone loss. This information is intended only for U.S. healthcare professionals. You may also want to do some research on your own. If youve noticed hair loss since starting Prolia treatment, talk with your doctor. Inflammation of the inner lining of the heart (endocarditis) due to an infection may also happen more often in people who take Prolia. You should also talk with your doctor if you have nausea during treatment. We comply with the HONcode standard for trustworthy health information. (2022). Because Prolia can also cause low blood calcium, your risk may increase if you receive Prolia. MEDICATION GUIDE Prolia (PR-lee-a) (denosumab) Specifically, Prolia works by blocking a protein called RANK. 2023 eHealthMe.com. Bone density decreases with time, and some people have a risk of developing weak or brittle bones. If the user is trying to grow bone due to osteoporosis, osteopenia, or any reason, the recommended intake is 4 capsules divided into 2 doses also taken in the morning and evening with food. If you cant properly absorb calcium or other minerals, be sure to talk with your doctor before using Prolia. If you have questions about treatment options for osteopenia or arthritis, talk with your doctor. Learn more about the FRAX score and the treatment options for, Medical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations. Do not share this medicine with another person, even if they have the same symptoms you have. (To learn more, see the Precautions for Prolia section below.). But if they become bothersome, talk with your doctor or pharmacist. For more information, you can refer to the drugs prescribing information. If youre able to become pregnant, your doctor will have you take a pregnancy test before you start Prolia treatment. You can use the study as a second opinion to make health care decisions. Motion sickness, nausea, and vomiting can occur as a part of vertigo. These side effects may be temporary, lasting a few days or weeks. It is important to check supplement labels to ensure that the product meets United States Pharmacopeia (USP) standards. Healthline Media does not provide medical advice, diagnosis, or treatment. To learn more about these two drugs, check out this drug article. Some rare side effects of Prolia can be serious and need medical attention. You can often relieve mild pain in your back or bones with an over-the-counter (OTC) pain medication. Coming to a Cleveland Clinic location?Hillcrest Cancer Center check-in changesCole Eye entrance closingVisitation and COVID-19 information, Notice of Intelligent Business Solutions data eventLearn more. Is the ketogenic diet right for autoimmune conditions? Vertigo (dizziness) was reported in some females* using Prolia for osteoporosis. If youve had surgery on your thyroid or parathyroid glands, you may have an increased risk of a low level of calcium in your blood. Certain kidney problems, such as chronic kidney failure, can cause a low calcium level in your blood. Various types of osteoporosis medications are available. The Prolia is making my leg bones and jaw bones hurt. But its not clear how often this side effect occurred in clinical trials. These problems may include: Your risk for mouth-related side effects may be higher if you have problems with your teeth. Call your doctor right away if you have signs of infection such as: swelling, pain, tenderness, warmth, or redness anywhere on your body; pain and burning when you urinate, painful urination; bladder infection (painful or difficult urination); lung infection (cough, shortness of breath); cold symptoms such as stuffy nose, sneezing, sore throat; This is not a complete list of side effects and others may occur. (Vitamin D helps your body absorb calcium.) This may help to protect healthy cells from damage. eHealthMe is studying from 146,783 Calcium users for its effectiveness, alternative drugs and more. You should use an effective method of birth control (contraception) during treatment with Prolia and for at least 5 months after your last dose of Prolia. Some people have developed unusual fractures in their thigh bone. It may also be higher if you have dental work done while youre taking Prolia. To learn more about this, see the How is Prolia administered? section below. More than half of American adults take an herbal or dietary supplement, and many more use over-the-counter or prescription drugs to manage maladies ranging from the occasional headache to chronic health conditions or mood disorders.. For many, it is part of their daily routine. Keep in mind that side effects of a drug can depend on: Additionally, you may experience different side effects from those listed below based on the condition youre treating with Prolia. You should not breastfeed while using this medicine. For more information about how these medications compare with each other, ask your doctor. This was one of the most common side effects in clinical trials of females who received Prolia for osteoporosis after menopause. you This increases your risk for bone fractures. Prolia is a prescriptionmedicine used to treat bone loss in women who are at high risk for fracture receiving certain treatments for breast cancer that has not spread to other parts of the body. They will also explain how much youll be given and how often. Your doctor may have you take extra calcium and vitamin D while you are being treated with Prolia. Your risk for some health conditions increases when you are postmenopausal. People need calcium for bone health and other functions. Xgeva is also used to treat giant cell tumor of the bone. Although its rare, your doctor may give you the option to self-inject Prolia at home. Instead, your doctor may recommend that you make certain changes to your diet, such as increasing your calcium and vitamin D intake. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Most Medicare plans and other insurance plans cover Prolia. A severe jawbone problem called osteonecrosis has rarely been reported with Prolia. Before you start Prolia treatment, talk with your doctor about how long Prolias side effects may last. Your doctor can check if you have osteoporosis, have low BMD, or have osteopenia by measuring your bone density. No, weight gain wasnt reported as a side effect of Prolia in clinical trials. If youre able to become pregnant, your doctor will order a pregnancy test for you before you take Prolia. Serious side effects of Prolia that have been reported include: For most people, Prolias side effects are mild and go away after a few days to a few weeks. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API). What should I know about Prolia vs. Boniva? Brush and floss your teeth as directed. Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once. Denosumab is contraindicated in women with hypocalcaemia. Prolia is also used to treat glucocorticoid-induced osteoporosis in men and women at high risk of bone fracture. Prolia is injected under the skin. This may include acetaminophen (Tylenol), naproxen (Aleve), or ibuprofen (Advil, Motrin). DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. But Zometa contains the active drug zoledronic acid. With arthritis, you have pain and inflammation of your joints. Dizziness from Prolia is usually mild and may go away on its own within a few days or weeks. WebProlia is used to treat osteoporosis in women after menopause and in men, and in people Your low blood calcium must be treated before you receive Prolia. Other side effects may continue for as long as you receive the medication, but they can often be relieved with other treatments. Prolia injections administered by a healthcare professional. Lifestyle changes that can help improve cholesterol levels include exercising regularly and eating a healthy diet. If your pain doesnt ease with OTC options, your doctor may suggest prescription pain medication. Below, we answer some common questions about taking Prolia. And ask your doctor about which drug is right for your condition. Sciatica was a less common side effect in females* who received Prolia for osteoporosis after menopause. Monoclonal antibodies are made to target and destroy only certain cells in the body. Bone pain from Prolia may be most noticeable in your arms and legs. What should I know about Prolia vs. Evenity? Coral calcium is also used in maxillofacial surgery and bone grafting. If you notice any tooth or jaw pain, or sensitivity while using Prolia, talk with your doctor or dentist right away. Prolia (Injection) Uses, Dosage & Side Effects - Drugs.com Calcium and Vitamin D: Important Musculoskeletal pain from Prolia is mild or manageable for most people. may occur. As with most drugs, Prolia can cause an allergic reaction in some people. Find out which foods can help. In addition, you should use effective birth control while youre taking Prolia. There is a potential for serious side effects to an unborn child. low calcium level--muscle spasms or contractions, numbness or tingly feeling (around your mouth, or in your fingers and toes). Common NOTE: This medicine is only for you. * Sex and gender exist on spectrums. But Prolia is given once every 6 months by a healthcare professional. These are serious. Mild side effects that have been reported with Prolia include: These side effects may be temporary, lasting a few days or weeks. But if the side effects last longer than that, bother you, or become severe, be sure to talk with your doctor or pharmacist. Serious side effects from Prolia can occur, but they arent common. Prolia was the right choice for me because it worked for me and it was 1 shot every 6 months. Theyll do this with certain tests, such as a bone scan or ultrasound. In this article well discuss the uses, side effects, safety precautions, and other important information about Prolia. Throw away a prefilled syringe after one use, even if there is still medicine left inside. If youd like to know more about the differences and similarities of Prolia and Evenity, see this comparison. While youre receiving Prolia treatment, your doctor will monitor your cholesterol levels with regular blood tests. Tell your doctor right away if you become pregnant while taking Prolia. Prolia isnt approved to treat osteopenia or arthritis. Get useful, helpful and relevant health + wellness information, 9500 Euclid Avenue, Cleveland, Ohio 44195 |, Important Updates + Notice of Vendor Data Event, low levels of calcium or Vitamin D in the blood, an unusual reaction to denosumab, other medicines, foods, dyes, or preservatives, medicines that lower your chance of fighting infection, steroid medicines like prednisone or cortisone, allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue, signs and symptoms of infection like fever or chills; cough; sore throat; pain or trouble passing urine, signs of low calcium like fast heartbeat, muscle cramps or muscle pain; pain, tingling, numbness in the hands or feet; seizures. Common interactions include nausea among females and fatigue among males. Store in the original container away from heat and light. They have some similar uses and side effects, but they also have some differences. But they each work differently because Prolia is a monoclonal antibody (it may also be called a miscellaneous bone resorption agent) and Reclast is a bisphosphonate which means they have different side effects, other uses, tolerability, and effectiveness profiles. Additionally, in Prolia-treated men with nonmetastatic prostate cancer receiving ADT, a greater incidence of cataracts was observed. If you have a low calcium level, you should not take Prolia. Osteoporosis medications and medication-related osteonecrosis of the jaw. But weight gain may occur with other medications you take or other health conditions you have. Others may continue for as long as you take the drug, but they can be easily managed. Generic name: denosumab (Prolia) [den-OH-sue-mab] People administered concomitant immunosuppressant agents (such as prednisone or cyclosporine) or with impaired immune systems may be at an even higher risk. With low BMD your bone tissues have less mineral, which means they become weaker. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Had parathyroid or thyroid surgery (glands located in your neck), Have been told you have trouble absorbing minerals in your stomach or intestines (malabsorption syndrome), Have kidney problems or are on kidney dialysis, Are taking medicine that can lower your blood calcium levels, Plan to have dental surgery or teeth removed, Are breast-feeding or plan to breast-feed. This helps treat osteoporosis by improving bone mass and strengthening your bones. While this drug may be prescribed for children as young as 13 years for selected conditions, precautions do apply. WebMost people can get adequate calcium through their diet if they make an effort. Women But if you look at D3 supplements online, youll see that most commercial supplements have higher doses usually either 1,000, 2,000, 5,000 or 10,000 IU. But if you think youre having a medical emergency, call 911 or your local emergency number. Theyll also discuss with you how to lower your risk for fractures by adding other treatments or making certain lifestyle or diet choices. For information about the difference between sex and gender, see this article. Symptoms may include jaw pain or numbness, red or swollen gums, loose teeth, gum infection, or slow healing after dental work. Prolia is used in adults to treat osteoporosis or bone loss in people who: who cannot use another osteoporosis medicine or these medicines did not work well. Prolia is a prescription medicine used to increase bone mass in men with osteoporosis who are at high risk for fracture. Prolia is used to treat osteoporosis in women after menopause and in men, and in people who are taking corticosteroids for 6 months or more.

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