Your doctor sounds JUST like mine did before I switchedpushing surrogacy and unwilling to try anything differently. We timed everything to my cycle. A Group Owner is a member that has initiated the creation of a group to connect with other members to share their journey through the same pregnancy & baby stages. More studies need to be done. Disclaimer: Any studies presented here may be contradicted by other studies. But after this chemical pregnancy from our PGS embryo, I have a gut feeling there is something else at play and am pushing my doctor for additional testing before another transfer since we only have 3 embryos left after 2 IVF cycles. sd84. He provides weekly summaries of the latest IVF research and posts on Facebook, Instagram and TikTok regularly. Liebermann et al. After I had my 3rd, my doctor and the IVF nurses all pushed for an ERA saying that even though Ive had prior success, that may have just been luck and my optimal window might be different than what I was doing. Im assuming as the levels drop theyll wean me off. Thank you TXtoCA, Im definitely planning to make changes. IVF is a numbers game. I also stopped working night shifts (Im a nurse) to reduce my stress levels but that didnt help either. If it were me and it was my last embryo I would definitely ask about (possibly even push for) immune protocol and the ERA just to cover all my bases. About 7 months later I transferred a day 7. I just officially confirmed another Chemical pregnancy for me. I guess this probably qualifies me as a poor responder which obviously doesn't feel good after all the other issues we've had. 35 years old For women 35-40 years old, there was no statistical difference (8.2% for PGT-A vs 11.0% for untested). PGT-A meta-analysis finds live birth rates only improve with older patients, Complete Guide to Embryo Grading and Success Rates, PGS testing doesnt improve success in good prognosis patients, No difference in euploid and mosaic embryo transfers: a clinical trial, Embryo biopsy of small embryos dramatically reduces IVF success rates, 144 abnormal (aneuploid/mosaic) embryos and their outcomes, Overall there was no statistical difference in miscarriage rates (9.9% in the, For women <35 years old, there was no statistical difference (11.2% for. Best of luck on your next FET! Neal et al. MENT I got a natural BFP at 34yo with an FSH of 38 and had no issues with my pregnancy. I go for my next Beta tomorrow. My RE didnt change a thing between round 1 and round 2, and I didnt do anything differently. Best of luck! For more background info, check out my post onPGS Testing. Design: Case-control study. He earned his MSc in 2012 for his research on inflammation and lung cancerand started Remembryo in 2018 to help people understand the evidence behind common IVF topics. Check mycomplete guide to mosaic embryosto learn more about mosaics, or mycomplete guide to PGT-Ato get more background on PGT-A (akaPGStesting). Sorry to hear about your recent cycle. Is it because they were early blastocysts? A genetically normal embryo has a 70% chance of a positive pregnancy test in any woman, whether she is 20 years old or 40 years old. While my clinic has had great success with PGS transfers they did say they expect implantation rates to end up averaging 90% for PGS normal embryos and I believe miscarriage rates are also lower. We are currently waiting on the PGS results from the frozens from our third cycle. Hello, I have one more embryo remaining. Thats a great suggestion, I will definitely ask my dr about doing an ERA. PGT-A is generally recommended for women >35, and the majority of cycles in the US in 2020 were for women >35 (62%). I am so frustrated, disappointed, hurt, sad and angry right now. Then a frozen cycle BFN. Simon et al. I'm 37 years old, and I just had a chemical pregnancy with a PGS-tested embryo. My first FET with my only normal embryo was successful but ended at 7.5 weeks with a MMC The devastation was unreal. Good luck and feel free to PM me. We have one (and only one) 4bb PGS normal embryo. My lining a week before transfer was 6.8, but trilaminar lining was present. Success rates for graded euploids are given here https://www.remembryo.com/pgs-success-rates/#Embryo_grades_and_PGS_success_rates. Tiegs (2020) in their multicenter prospective study transferred 414 blastocysts that were only tested using PGT-A after the pregnancy outcome.So no one knew what was being transferred. Reply Share React AMB425 Sep 2, 2016 11:01 AM This November I did a frozen transfer with an untested, five day embryo and Im 9 weeks now. (2014)found no difference inongoing pregnancieswith Day 5 or 6 euploids (about 50%). Some background on us: diagnosed with severe male factor IF 4 years ago, did one round of IVF/ICSI which resulted it a chemical pregnancy. You cant compare the per retrieval and per transfer stats against each other directly. I feel like your doctor should have mentioned the ERA and biopsy by now. I also went for a lot of second opinionsall of the drs said there were many reasons and theories for why pgs embryos fail but its not uncommon. MENTS I am also going through a chemical pregnancy this week, but with an untested embryo (so, that's very likely the reason for my loss). Euploid embryos are believed to have higher success rates and a reduced chance of miscarriage. The usefulness comes when someone who is starting IVF and considering PGS testing. I just received news today that out of our 14 blastocysts only 4 passed pgs and 1 with no result that we are retesting. Ive done intralipid infusions and Neupogen each time in the case I had an autoimmune disorder or natural killer cells so I dont think that would be the issue. This was our first trial. My current success was a FET with NO meds except vaginal progesterone. So the next step is transfer and my clinic is telling me to go for era in order to increase my chances. Next Generation Sequencing (NGS) is a new technique which boasts an impressive 99.98% consistency rate for its results. Viotti et al. thats a great suggestion! ALL THREE DID!!! I was wondering what protocol were you on for your second transfer? Thanks for sharing! However, theirsample sizewas small. (2021) in their retrospective multicenter study compared the transfer of 1000 mosaic embryos and over 5500 euploid embryos between 2015 and 2020. Did your RE have you take anything other than progesterone and estrogen and aspirin? A pregnancy that doesn't even make it to the 6 week scan where they can usually see the fetus on an ultrasound. what were the extra things you did besides Lovenox/prednisone, biopsy and ERA? Im going to try and run it by her again to see what she thinks. is there another clinic in your area you can switch to? It provides a greater scope of information to geneticists, it reveals mosaicism within the embryos, as well as minimising the risk of receiving false positive or negative results. Out of the 6 that were pgs tested, 3 came back normal and 1 came back inconclusive. Group Leaders arent expected to spend any additional time in the community, and are not held to a set schedule. I didnt realize you could transfer your embryos to another clinic. To perform the biopsy, an embryologist removes 2-10 cells from the precursor placenta cells of the blastocyst embryo, called the trophectoderm. If you haven't had multiple losses/failed attempts feel free to comment but please be empathetic when doing so. Though it's one of the most successful forms of assisted reproductive technology, the live birth rate from one IVF cycle is about 55.6% for people under 35, and 40.8% for folks between the ages of. Most assume theyll get the stats that are reported per transfer without knowing if theyll get eligible blasts or not. Tiegs (2020) in their multicenter prospective study transferred 414 blastocysts that were only tested using PGT-A after the pregnancy outcome. He provides weekly summaries of the latest IVF research and posts on Facebook, Instagram and TikTok regularly. I am so so sorry. Its so heartbreaking but Im trying to find some hope so I can move forward. Started with 14 eggs, 7 fertilized and only 1 made it to blast and ended up being abnormal. Pregnancy rates will be higher because not everyone will have a live birth (some miscarry). If you feel a message or content violates these standards and would like to request its removal please submit the following information and our moderating team will respond shortly. But what about the women who didnt get blasts? This was my only PGS normal embryo so I have to re-do that as well.. Dear RLM11, so sorry for your losses, I know how devastating it is! I also know that no one can make this decision for me. The other two are on ice. I have expressed my concern but my RE believes it is more about the pattern. Ive had two biochemical losses with day 6 4BC euploids and with 1 day 6 4BC left to try, Im wondering our odds. Then she went into all of the horrible statistics with twin pregnancy. Hoping to hear from them soon . I know Ive had issues with my lining but for each of the chemical pregnancies we were able to get my lining to at least 8mm with a mixture of puregon and cetrotide injections, instead of estrace, as well as PRPs. I would like to use the delestrogen shots next time instead of the patches and pills which seem to do nothing for me. There was a greater reduction in the >35 group (10.4% for PGT-A vs 27.9% for untested) compared to the <35 group (13.3% for PGT-A vs 16.1% for untested), however neither of these analyses were statistically significant. Group Leaders communicate with staff moderators and escalate potential violations for review, but they dont moderate discussions. I"ve not had a chance to actually talk with my RE yet, hopefully I will tomorrow after I go back for monitoring. Maybe the wash too? They may be able to use the same sample as the ERA if you do both. So crazy that its what finally worked. My doctor is recommending a Receptiva test to uncover any other reasons why the pregnancies won't last. Do embryo biopsies for PGT-A match the rest of the embryo? Has anyone had this happen and did any further testing determine the cause? Chemical pregnancy facts. Ive seen conflicting studies with some (irani 2017) saying poor quality euploid has just 25% LBR but some more recent studies (2021) that suggest that morphology matters more under 30 (which Im not Im 42 but was 37/8 at retrieval). (2016)looked at over 18,000 Day 5 embryo biopsies (usingthe older SNP technology) and reported the chances of an embryo beingeuploid(based on age): So up until 37 theres about a 50% chance of each blastocyst being a euploid, this cuts in half to about 25% at 42. I also tested positive for anti-thyroid antibodies. Hello, This test can identify chromosomally normal embryos, which increase the chances of a healthy pregnancy. In this post well learn more about IVF with PGS success rates for euploid embryos. For this group theyll have a better idea of what to expect. As mentioned in the study, about 72% of mosaic miscarriages occurred between observation of the gestational sac (3-5 weeks after transfer) and fetal heart beat (6-8 weeks after transfer). in reply to 3 years ago Thank you so much! Terms are highlighted every 3rd time to avoid repetition. I could tell that my dr thought we could just try again but she knew I needed to check something to feel ok with it. I went into my second egg retrieval and got less eggs than the first time around. But if you dont like the extra meds you could talk with your current or new clinic about not doing it and get their thoughts on it. (2014)found no difference inongoing pregnancybetween grades (about 50% for each category). Sometimes something as small as a polyp that can be removed, can cause implantation to fail. See the chart below from the CDC (2016 data): In this post well look at the different miscarriage rates that all these types of PGT-A tested embryos have. We know about the epigenetic issue from testing the sperm but its not a test that you can do on the embryos (would have to kill them), I hope you are able to figure out what is going wrong and fix it! I think it would be worth it to do a endometrial receptivity analysis to test your implantation window. They found that: If you want to read my summary of this paper, check here. Embryos with the right number of chromosomes are called euploid and may have a higher chance of making a pregnancy, although the evidence for this is controversial. She was also concerned with the previous doctors aggressive surgery protocols, and my age was also a factor. Normally, we have 23 pairs of chromosomes (or 46 in total) one pair comes from the egg from our biological mother, and the other comes from the sperm from our biological father. Is it significantly less for a pregnancy with an embryo that tested pgt normal? It is seriously invaluable to me. Find advice, support and good company (and some stuff just for fun). One clinic determined IVF with PGS success rates to have a 10% higher pregnancy rate. END MENTS We really expected to find success with our first pgs transfer even though our company and RE only quoted 60% odds per embryo transferits a good but tough reminder that its not expected to always work. Fast Facts About PGS Testing Risks. Whitney et al. Both Chemical pregnancies my lining was under 7. Thought just because your embryo iseuploidthat grades dont matter anymore? Group Leaders arent expected to spend any additional time in the community, and are not held to a set schedule. These stats are based off many people, so your results may not exactly hit the average.

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